When a group of subway construction workers accidentally uncover an ancient door, that is not meant to be opened until Doomsday, their persistence accidentally triggers the doors opening, which sends incredible amounts of poltergeist energy surging through the New York subway system, transforming the trains into worm-like monsters. The Ghostbusters are called in to deal with it, and Egon discovers that if they don't close the door soon, the entire world will be transformed into a twisted and barren wasteland of ghostly and demonic creatures that will replace all of humankind and civilization the world over.
Ghosts with plans for world domination create a TV station as part of their scheme. Manifesting as various television characters and commercial products, the ghosts can travel through any television in the city to terrorize the public. The Ghostbusters try to stop these ghosts, but when Slimer gets captured by the ghosts, it's up to the guys to get him back and make sure the ghost station does not go nation-wide, and then world-wide!
A ghostly bayou trumpet player, Malachai, is living—sort of—in the past, and seeks to turn back the clock by playing a haunting rendition of "When the Saints Come Marching In". Can the Ghostbusters, with help from a bewitching bruja woman, fight this time-warping menace?
When a treasure-seeker uncovers a treasure chest on the ocean floor, he unwittingly summons a ship of pirate ghosts, who wreak havoc on New York in order to reclaim their treasure. The ship, called The Stag, is commanded by Captain Jack Higgins, one of the most notorious pirates in history, whose pirates prove to be too much for the Ghostbusters to handle. Despite being outnumbered, the Ghostbusters give chase to the pirates in order to stop them. To make things worse, Slimer tries to help, and gets into a fight with a ghost parrot, while the guys take on Higgins and his pirates, ambushing The Stag first from another land-beached ship, and then leading the pirates into a trap so that they can end their plundering once and for all.
Ray's aunt hires some phony psychic to get rid of ghosts in her house, much to the Ghostbusters' dismay. Instead of helping, though, this phony psychic enrages the ghosts, who are, in fact, protective house spirits called domovoi, even more, causing them to throw a nasty temper tantrum.
It is not suitable for a Spengler to be anything as unscientific as a Ghostbuster, at least in the eyes of Egon's Uncle Cyrus. Egon has to reluctantly go back to the midwest, over 1500 miles from New York, and feed mice at the Spengler Labs, but the Ghostbusters will try anything to convince Uncle Cyrus that there actually are such things as ghosts. But things get out of hand when Uncle Cyrus unwittingly lets the Staypuft Marshmallow Man out of the Containment Unit, and the Ghostbusters have to put him back before he destroys the city again.
Frank Welker
Ray Stantz / Slimer
Arsenio Hall
Winston Zeddemore
Lorenzo Music
Peter Venkman
Laura Summer
Janine Melnitz
Dave Coulier