Cole finds himself in 2017 at the height of the plague. Out of options, Jones faces an impossible choice to replace the Core.
Forces come to a head when Ramse does what it takes to protect his newfound family, leaving Cole to deal with the aftermath.
Cole's last-ditch effort to stop the Army of the 12 Monkeys brings him to Tokyo in the year 1987.
With Cole dying from the effects of time-travel, Railly must find the one person who can save him.
In the season finale, Cole and Railly attempt a final confrontation with their closest enemies, and Jones faces a new threat to all that she's accomplished.
Cole and Ramse repair their broken friendship while on the run; Railly and Jones navigate an uncertain future in 2043.
Cole gets stranded in 2016 after an attempt to destroy the virus changes the future; Jones and Railly deal with the consequences of the changed timeline.
Despite growing tension between them, Cole (Aaron Stanford) and Cassie (Amanda Schull) embark on their first time travel mission together, splintering to New York at the height of World War II. In this sepia-drenched, bygone era, the pair track a dangerous member of the Twelve -- a seductress who is on a mission of murder that could ultimately shatter time itself.
When Cole (Aaron Stanford) and Cassie (Amanda Schull) are stranded in 1944, Jones must turn to the person she trusts the least to bring them home - Ramse (Kirk Acevedo). For Ramse, this mission will give him a chance to atone for his sins -- but can he mend the broken relations between Cole and Cassie? Meanwhile, Jones (Barbara Sukowa) visits old Jennifer Goines (Emily Hampshire) to explore the true nature of Time - and the Twelve's method to destroy it.
In the present day, Cassie (Amanda Schull) and Jennifer Goines (Emily Hampshire) are on the run from the 12 Monkeys in a desperate attempt to unravel the next part of the conspiracy. Meanwhile, in 2044, Cole (Aaron Stanford) and Ramse’s (Kirk Acevedo) conflict with Deacon (Todd Stashwick) comes to a head.
Cole’s (Aaron Stanford) partnership with Ramse (Kirk Acevedo) is put to the test when they travel to New York City of the 1970s to prevent the Twelve from murdering a disturbed Vietnam veteran with a connection to the Witness.
Barbara Sukowa
Jones
Emily Hampshire
Jennifer Goines
Amanda Schull
Dr. Cassandra Railly
Kirk Acevedo
Ramse
Aaron Stanford
James Cole