Snowball (recurring guest star voice talent Roddy McDowall), an evil hamster that also wants to take over the world, interrupts The Brain's chain-letter scheme. Ironically, The Brain must now save the world so that it will be available to conquer the following night.
In 19th-century England, Pinky and The Brain accept a challenge to circle the globe in 79 days in order to gain a foothold in the British Empire ...and then conquer the world.
After purchasing carefully selected properties, The Brain schemes to flood the planet and leave his holdings as the only dry land. He and Pinky bluff their way onto the space shuttle to manipulate the Hubble telescope and focus the sun's rays on the polar ice caps, melting them. But The Brain has made a fatal error in his real estate dealings, which foils the plans.
Pinky and The Brain mechanize the Lincoln Memorial and convince the population that it's the reincarnated Lincoln in "Ambulatory Abe." Then, The Brain tells the story of the "Mouse of La Mancha."
First, Pinky arrives in Vienna circa 1946 to search for his missing friend, The Brain, in "The Third Mouse." Next, in "The Visit," The Brain captures some ordinary field mice that are found to be his parents.
The Brain convinces everyone to come over to an alternate Earth that he has created out of paper mache.
In "Collect 'Em All," Brain uses Johannes Gutenberg's printing press to make up collectable trading cards. In "Pinkasso," Pinky becomes a famous modern artist..
Pinky and The Brain are chased by an alien that eats brains.
Pinky becomes President of the United States when a letter to the newspaper is misconstrued as a strong political viewpoint.
Brain schemes to create a tearjerker movie that will be broadcasted to the entire world and the world's leaders will be so depressed they will relinquish power to him.
The mice are mistaken for monkeys and are taken from Acme Labs and set free in the jungle.
Maurice LaMarche
The Brain
Tress MacNeille
First Lady
Frank Welker
The President
Tom Ruegger
Producer
Barbara Gerard