LEVELS – A Whole New Level Levels

A lean mass hyper-responder is someone with high LDL and HDL cholesterol and low triglycerides. They are often lean and healthy people who present with strange and alarming lipid numbers after going on the ketogenic diet. Dave Feldman, Dr. Nick Norwitz & Dr. Dominic D’Agostino discuss the LMHR phenotype, whether it’s a concern, whether it’s rare, the Oreo vs statin study, how exercise levels might play a role, and why more research is needed.



Sign Up to Get Your Free Ultimate Guide to Glucose: ⁠⁠⁠https://levels.link/wnl⁠⁠⁠



Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health.

Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health.



🎙 What Dave Feldman, Nick Norwitz, PhD, & Dominic D’Agostino, PhD, discuss:

(4:29) — What is the lean mass hyper-responder phenotype?

(8:32) — Often the LMHR phenotype gets noticed when someone goes low carb

(19:02) — The Oreo cookie study garnered attention for the LMHR phenotype

(25:32) — Understanding the mechanisms of the LMHR

(40:04) — Exercise levels likely play a role in LMHR

(51:26) — The alarming LDL levels in LMHR prompted research

(59:25) — The “gym hypothesis” will be important for further research

(1:10:48) — An open and respectful dialogue is needed on the topic

(1:33:47) — The importance of additional research

⁠⁠Transcripts & Show notes⁠⁠⁠

🔗 Helpful links:

Watch the conversation: ⁠https://youtu.be/ItNGrGNvESY

Writing an evidence-based nonfiction book requires time, dedication, and a true passion for the content. Dr. Casey Means and her brother Calley Means joined forces to create their book “Good Energy: The Surprising Connection Between Metabolism and Limitless Health.” Casey Means, MD, and Mike Haney discuss the book-writing process, insights into creativity and inspiration, the steps to seeking an agent and selling a book to a publisher, and the trials and tribulations along the way.



Sign Up to Get Your Free Ultimate Guide to Glucose: ⁠⁠https://levels.link/wnl⁠⁠



Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health.

Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health.



🎙 What Casey Means, MD, & Mike Haney discuss:

(05:47) — Bringing joy and empowerment to conversations about health

(10:20) — Landing an agent

(13:56) — The book proposal

(21:41) — The challenges of keeping content clear and accessible

(29:01) — On collaboration

(30:06) — The writing process has a lot of moving parts

(35:59) — On determining your voice

(43:21) — Carving out dedicated time to write

(55:11) — A health coach can help you stay accountable

(1:07:45) — The magic of putting a book into the world

(1:13:03) — On facing feedback

⁠Transcripts & Show notes⁠⁠

🔗 Helpful links:

Watch the conversation: https://youtu.be/3dveHuhZld4?si=ke_MDmjTcUPB5YqQ⁠⁠

Insulin resistance is when cells stop responding to insulin’s signal to uptake glucose. It’s a hallmark of prediabetes, Type 2 diabetes, and other forms of metabolic dysfunction, and it manifests as several chronic disease, ranging from Alzheimer’s to polycystic ovarian syndrome. Dr. Rob Lustig and Dr. Dominic D’Agostino discuss the importance of monitoring insulin levels, why a high or increasing insulin level is a problem, and how insulin resistance hinders weight management.



Sign Up to Get Your Free Ultimate Guide to Glucose: ⁠https://levels.link/wnl⁠



Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health.

Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health.

🎙 What Rob Lustig, MD, & Dr. Dominic D’Agostino, PhD, discuss:

(03:57) — What is insulin?

(06:55) — What is insulin resistance?

(18:00) — There are three types of insulin resistance

(38:00) — Weight management is not about calories in and calories out

(45:53) — Adding more insulin to the equation of Type 2 diabetes isn’t necessarily the answer

(51:20) — Insulin is a crucial biomarker to measure for metabolic health

(53:58) — Insulin resistance is a hinderance to weight management

(57:07) — The intake of too much leucine can lead to insulin resistance

(1:02:04) — Fiber feeds the gut microbiome and is crucial for metabolic health

(1:13:11) — Is intermittent fasting necessary?

⁠Transcripts & Show notes⁠

🔗 Helpful links:

Watch the conversation: ⁠https://youtu.be/dFOaBrujDHo⁠

The ketogenic diet is a low-carbohydrate, high-fat diet that has proven benefits for brain health. Research shows that the keto diet helps ease symptoms of some mental health conditions, including depression and bipolar disorder. But no diet, even keto, is one-size-fits all. Dr. Georgia Ede and Dr. Dominic D’Agostino discuss how diet and brain health are connected, how diet and gut health affect brain health, and how a ketogenic or other low-carbohydrate diets can be tailored to people’s specific needs.



Sign Up to Get Your Free Ultimate Guide to Glucose: ⁠⁠https://levels.link/wnl⁠⁠



Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health.

Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health.



🎙 What Georgia Ede, MD & Dominic D’Agostino, PhD, discuss:

(06:51) — Dr. Georgia Ede describes her interest in nutritional science for mental health

(16:45) — Metabolic health is tied to brain health

(23:16) — A ketogenic diet vs medications for mental health

(27:19) — A ketogenic diet can be tailored to prevent side effects

(32:51) — Gut health and mental health are connected

(39:00) — Diet is highly individual

(42:02) —CGM can teach people how foods and diet strategies affect their health

(44:57) — Following a low-carbohydrate diet will generally reduce insulin levels and triglycerides

(47:40) — Some psychiatric symptoms have links to higher C-reactive protein levels

(48:42) — Dr. D’Agostino summarizes one of Dr. Ede’s studies on the ketogenic diet and mental health

(56:59) — A ketogenic diet may also help ease some menopause symptoms

⁠Transcripts & Show notes⁠

🔗 Helpful links:

Watch the conversation: ⁠⁠https://youtu.be/kBjBEjV0vqU⁠

Find us on YouTube: ⁠⁠https://youtube.com/levelshealth?sub_confirmation=1

Not all calories are equal. Tracking your macronutrient intake, using AI capabilities, can help you improve your body composition, facilitate weight loss, and boost exercise performance. The three macronutrients are protein, fat, and carbohydrates, with fiber a subset of carbs. Josh Clemente & Dr. Dominic D'Agostino discuss the new macros-tracking feature in the Levels app, the purpose and importance of each macronutrient, how to use macros-tracking in conjunction with biomarker data to improve health and fitness, and how easy the app’s AI functionality is to use.



Sign Up to Get Your Free Ultimate Guide to Glucose: ⁠⁠⁠⁠⁠https://levels.link/wnl⁠⁠⁠⁠



Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health.

Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health.



🎙 What Josh Clemente & Dominic D'Agostino, PhD, discuss:

(09:03) — The importance of prioritizing protein intake

(17:03) — Why is tracking macros beneficial?

(21:11) — Each macronutrient has a different role in the body

(39:36) — The different functions of macros

(48:32) — Is excess protein a concern?

(54:55) — The problem with excess carbohydrates

(1:00:37) — Tracking macros can help you improve metabolic flexibility

(1:02:41) — The issue with overconsumption of carbohydrates

(1:17:18) — Is fiber a macronutrient?

(1:46:21) — Macros tracking in the Levels app

(1:49:50) — Tracking macros can help improve body composition and performance

Transcripts & Show notes

🔗 Helpful links:

Watch the conversation: https://youtu.be/wg76Q25Ngd4

Find us on YouTube: ⁠⁠⁠⁠⁠https://youtube.com/levelshealth?sub_confirmation=1⁠⁠

Fructose and its byproduct uric acid may play a role in the development of Alzheimer’s, thanks to an evolutionary adaptation hijacked by the modern diet. Fructose can be directly consumed, or the body can convert high-glycemic carbohydrates and other foods to fructose. Fructose suppresses some cognitive functions. Dr. Richard Johnson and Dr. Rob Lustig discuss a new study, of which Johnson was an author, on how fructose may be a potential driver in Alzheimer’s, and they hypothesize about fructose’s potential connection to the development of other conditions.



Sign Up to Get Your Free Ultimate Guide to Glucose: ⁠https://levels.link/wnl⁠



🎙 What Richard Johnson, MD, & Rob Lustig, MD, discuss:

(09:50) — Fructose is the driver of some diseases that are on the rise in kids

(11:53) — Fructose is a driver of obesity and metabolic syndrome

(15:36) — Pharmaceutical treatments for Alzheimer’s disease aren’t as effective as researchers had hoped

(17:32)— The research focus of Alzheimer’s is slowly shifting to understanding insulin resistance in the brain

(20:41) — Is fructose a root cause of Alzheimer’s?

(26:26) — New research suggests fructose induces a foraging response

(28:20) — Fructose inhibits areas of the brain to encourage successful foraging

(46:48) — We need more research on fructose

(1:03:10) —Is fructose a factor in violence?

⁠Transcripts & Show notes⁠

Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health.



Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health.



👋 WHO WE ARE:

Levels helps you see how food affects your health. With real-time, personalized data gathered through biosensors like continuous glucose monitors (CGM), you learn which diet and lifestyle choices improve your metabolic health so you can live a longer, fuller, healthier life.



🔗 LINKS:

Could Alzheimer’s disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism?: ⁠https://www.sciencedirect.com/science/article/abs/pii/S0002916523000047?dgcid=author⁠

Subscribe here on YouTube: ⁠https://youtube.com/levelshealth?sub_confirmation=1⁠