1,133 episodes
This Week in Virology Vincent Racaniello
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- Science
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4.7 • 182 Ratings
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TWiV is a weekly netcast about viruses - the kind that make you sick. Brought to you by four university professors and a science writer.
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Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles, and H51 influenza infection of birds, poultry and cows before and SARS-CoV-2 circulation, before discussing if the original monovalent SARS-CoV-2 vaccine was effective in children and adolescents, how to use words to properly describe respiratory pathogens the guidelines for spring administration of COVID vaccines boosters, discusses the emergency use application of a pre-exposure prophylactic, revised guidelines for how to treat respiratory viral infection guidelines by the CDC, continues to dispel the myth of viral rebound, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if administration of remdesivir reduces mortality, long COVID, persistence of virus infection during long COVID and it prevalence. For more information about this body of work, listen to TWiV 1088.
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Links for this episode Measles tracking (CDC) Cows, chickens and birds H5N1….oh, my (USDA) Evolution of circulating H5N1 (CIDRAP) COVID-19 national trend (CDC) COVID-19 deaths (CDC) Original monovalent mRNA vaccine effectiveness in children and adolescents (MMWR) Updated terminology for pathogens transmitted through the air (WHO) Are these really better definitions for pathogens transmitted through the air (NY Times) Pharmaceuticals for diseases spread through the air (Reuters) Older adult spring booster available (CDC) Advisory committee for immunization practices slides (CDC) Advisory committee for immunization practices spring 2024 COVID-19 boosters (CDC) EUA for pemgarda (FDA) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (IDSociety) WHO vs national guidelines for COVID-19 therapeutics (BMJ) COVID-19 and the bay of pigs (UNC) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (IDSociety) Outpatient treatment with concomitant vaccine-boosted convalescent plasma (mBio) Updated respiratory virus guidances (CDC) What do when your heathcare provider is infected with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Remdesivir associated with reduced mortality of hospitalized oxygenated patients (OFID) Long COVID evidence based review TWiV shout out (TWiV 1088) Long COVID prevalence among adults (MMWR) Persistence of SARS-CoV-2 infection (Lancet Infectious Diseases) More questions, new answers long COVID (Lancet Infectious Diseases) Contribute to our ASTMH fundraiser at PWB Letters read on TWiV 1108 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv -
Uncoating some envelopes
It has been a long time since TWiV has released an all listener email episode, and if you have been waiting for one, then this episode is for you! (and everyone else of course).
Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) The New City by Dickson Despommier (blog post) International Conference on Pandemic Preparedness Letters read on TWiV 1107 Timestamps by Jolene. Thanks! Weekly Picks Brianne – Cats Are Perfect. An Evolutionary Biologist Explains Why
Alan – Bardcore music by Hildegard von Blingin’
Vincent – A quote from Georgia O’Keefe: “I think it’s so foolish for people to want to be happy. Happy is so momentary – you’re happy for an instant and then you start thinking again. Interest is the most important thing in life; happiness is temporary, but interest is continuous”. From the dailyphilosopher
Listener Picks Julia – Recent success in troubleshooting autoclave challenges
Charmaine – Viruses, myelin, the evolution of complex life, and the Fermi paradox
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv -
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles, potential risk factors for severe disease following influenza infection before and SARS-CoV-2 circulation, before discussing if SARS-CoV-2 infection impacts sperm fertility, the guidelines for spring administration of COVID vaccines boosters, discusses the emergency use application of a pre-exposure prophylactic. revised guidelines for how to treat respiratory viral infection guidelines by the CDC,continues to dispel the myth of viral rebound, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, and long COVID. For more information about this body of work, For more information about this body of work, listen to TWiV 1088.
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode Measles tracking (CDC) Influenza risk factors for potential severe outcomes (OFID) COVID-19 national trend (CDC) Does SARS-CoV-2 infection influence sperm quality (Scientific Reports) Spring COVID-19 booster recommendations (CIDRAP) Older adult spring booster available (CDC) Advisory committee for immunization practices slides (CDC) Advisory committee for immunization practices spring 2024 COVID-19 boosters (CDC) Slide 19 (CDC) EUA for pemgarda (FDA) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (IDSociety) Nirmatrelvir for vaccinated or unvaccinated COVID-19 patients (NEJM) Nirmatrelvir/ritonavir vs. remdesivir for treatment of high risk outpatients (Therapeutic Advances in Infectious Disease) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (IDSociety) Outpatient treatment with concomitant vaccine-boosted convalescent plasma (mBio) Updated respiratory virus guidances (CDC) What do when your heathcare provider is infected with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Long COVID evidence based review TWiV shout out (TWiV 1088) Contribute to our ASTMH fundraiser at PWB Letters read on TWiV 1106 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv -
All the T and B in China
TWiV reviews influenza H5N1 in North American cows and in birds throughout New York City, polio health emergency extended, ChatGPT to control vaccine hesitancy, increasing viral hepatitis worldwide, dengue public health alert in Puerto Rico, cherry trees drowning in Washington DC, death of iron lung Paul, origin and dispersal history of hepatitis B virus in Eastern Eurasia, and antibody-independent protection against heterologous SARS-CoV-2 challenge.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) The New City by Dickson Despommier (blog post) Navigating the U.S. Immigration System webinar International Conferene on Pandemic Preparedness Avian influenza in dairy cows North Carolina and South Dakota H5N1 clade 2.3.4.4 Pathogenic flu throughout NYC Polio from Afghanistan to Pakistan extending public health emergency CHAT GPT to combat vaccine hesitancy Viral hepatitis worldwide Dengue public health alert in Puerto Rico Cherry trees being drowned by water level rise in DC Paul in iron lung dies (NPR) Hepatitis B virus in Eastern Eurasia (Nat Comm) Antibody-independent protection against heterologous SARS-CoV-2 (Nature) Timestamps by Jolene. Thanks! Weekly Picks Brianne – Do Other Planets Have Solar Eclipses?
Kathy – Radcliffe Wave and Mt. Etna smoke rings with video
Rich – Spongy Oak Apple Gall Wasp (Amphibolips confluenta) Life cycle; Gall formation
Alan – Rogue attempt to clone giant sheep for captive hunting
Vincent – The Scientists Rock. Literally.
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv -
Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles before addressing results of Pfizer’s phase 3 RSV vaccine clinical trial for adults under 60, RSV, influenza and SARS-CoV-2 circulation, differences between rural and urban communities dealing with SARS-CoV-2 infections, the latest statistics on influenza and COVID-19 circulation, restates the guidelines for spring administration of COVID vaccines boosters, discusses the emergency use application of a pre-exposure prophylactic. revised guidelines for how to treat respiratory viral infection guidelines by the CDC, continues to dispel the myth of viral rebound, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, how long COVID affects the brain and associates with an increase in allergic incidents as well as if post SARS-CoV-2 infected patients are unable to exercise or have functional limitations. For more information about this body of work, listen to TWiV 1088.
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode Measles tracking (CDC) Measles just this year (MMWR) ABRYSVO phase 3 results (Pfizer) RSV surveillance (CDC) Influenza/flu surveillance (CDC) Provisional deaths due to COVID-19 (CDC) COVID-19 national trend (CDC) COVID-19 wastewater testing (biobot) Variant tracker (CDC) Rural-urban differences in COVID-19 mortality and hospitalizations (OFID) Spring COVID-19 booster recommendations (CIDRAP) Older adult spring booster available (CDC) Advisory committee for immunization practices spring 2024 COVID-19 boosters (CDC) EUA for pemgarda (FDA) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Nirmatrelvir for vaccinated or unvaccinated COVID-19 patients (NEJM) Assessment for clinical usefulness (NEJM) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (IDSociety) Updated respiratory virus guidances (CDC) What do when your heathcare provider is infected with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Long COVID evidence based review TWiV shout out (TWiV 1088) Brian and cognitive changes in long COVID patients (BRAIN) Allergic disease incidents after COVID-19 (Nat Comm) Can post COVID patients exercise or do they have functional limitations (JAMA Network Open) Contribute to our ASTMH fundraiser at PWB 37:06 Letters read on TWiV 1102 37:56 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv -
Jason 'Spike' McLellan
Vincent travels to the University of Texas in Austin to speak with speak with Jason McLellan about his career and his research on the SARS-CoV-2 spike protein, including the effect of adding two proline residues, its effect on other viral spike glycoproteins, and general approaches to vaccine design.
Hosts: Vincent Racaniello and Rich Condit
Guest: Jason McLellan
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) The New City by Dickson Despommier Prefusion-stabilized SARS-CoV-2 spikes (Science) Structure-based vaccine design (Curr Opin Immunol) Prefusion-stabilized SARS-CoV-2 S2-only antigen (Nat Comm) Stabilized coronavirus spike stem elicits broadly protective antibody (Cell Rep) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Customer Reviews
I’m grateful
As always a great and entertaining conversation between flexible and informed thinkers. Just listened to the episode with Paul Offit whose book I’m currently reading. Both realistically saddening and hopeful in that there are many people working hard on educating as many as they can reach. Thanks for what you do.
Thanks!
I love the hosts - Banter, insights, picks…I Listen to every episode. I’m able to recognize virology lingo, which makes me feel smart, even if I don’t remember how it all fits together.
Episode 1017. Facts vs lying by omission on lab leak hypothesis.
I am not a virologist. However, I am very ware of the scientific method.
This episode really exposes how NOT to prove your point that SARS COV-2 was not a lab leak.
One guest was not prepared or simply had her facts wrong. I heard her mention “bat guano was most likely a low risk.” However, much of the leaked documentation available to anyone who wants to read it states that rectal swabs and serum was taken from bats.
Additionally, you had one person admittedly play the devils advocate and bring up several “points the lab leakers use.” He seemed embarrassed to even bring this up. Maybe get some people in your field that can seriously have a debate that really believe what they say.
Also, there are emails from some very prominent French virologists going back and forth explaining the concerns with safety and poor compliance with following safety protocols.
Also, at one point one guest said that “engineering viruses is extremely difficult.” However, it is well established that Corona viruses have been engineered previously difficult or not.
The furin cleavage site has already been added to other viruses and your guests poopooed this fact which is well documented. And furthermore you bring up the most Baird claims from the “lab leakers” including the HIV stuff. This sounds clearly like you bring the most absurd crap to prove that anyone who has other beliefs are homophobes or xenophobic.
Also, when you say that “the lab leakers” have no proof. Neither do the esteemed well learn-Ed docs on your show. You people aren’t true scientists as you appear to just throw out concerns and beliefs from many others in your field as crackpots. No debate. No attempt to validate your hypothesis.
Dr. Daszac clearly was concerned about losing funding and strong armed many of your colleagues to disavow the idea that this virus could have leaked from a lab. Interestingly, many of these people had been texting Dr. Fauci with concerns the virus appeared engineered. And within days these same scientists (who apparently are simpletons to the the TWIV squad) suddenly within 4 days signed the Lancet letter telling us average joes and average Joe virologists and epidemiologists (we just set around in trailer parks unless we are at a trump rally or shopping at Walmart for guns ) how questioning the Chinese makes us racist.
I am educated and have a MS in a science based field. I know how the scientific method works. You and your team literally threw your colleagues under the bus. No debate. You all should know better that the question of where this virus came from is very relevant to prevent the next one.
You want to get the politicians to bring the heat level down on this very important research? Have an honest debate and present your evidence to those virologists and epidemiologists who disagree. Or not and get all the funding cancelled.
The TWIV team discounts the department of energy, the FBI, MI6, and about 17 other intelligence agencies from other countries.
TWIV, your guests on this episode, Daszac, Rasmussen, are either much much smarter than everyone else or really the smartest idiots in the room.
Sincerely
The Dude
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