Cat breaks up with Glenn, and Lola fakes a brain tumor to dump Owen. Later, they "console" each other. Blake is a sad clown, and Owens ex-partner tries to lure him back to be a cop. American forces raid the hills of Pakistan in search of bin Laden.
The staff is sympathetic about Lolas fake brain tumor. Glenn is arrested for trying to give an infant breast implants. Briggs recalls Owens last day as a cop. Blakes healing powers of laughter are lacking. Cat falls in love again. Still no bin Laden.
Blake recalls childhood traumas that made him who he is. A competing clown doctor arrives to threaten Blakes position. A visiting doctor experiences the hospital in a whole new way in this very special episode introduced by executive producer David Wain.
Cat's new love affair blossoms, provoking jealousy in Glenn. A visiting neurosurgeon, Dr. Max Von Sydow, offers to cure the Chief of her myriad ailments. Cat deflowers her now boyfriend while Blake challenges Schachter to a laughter-off.
Jealous Glenn gives Cats new boyfriend an unscheduled operation. Osama bin Laden is captured! Blake operates on Lolas non-existent brain tumor while the Chief undergoes major surgery. Will they make it? Probably not. But maybe. OK, one of them dies.
As the new season begins, Cat Black is conflicted about her full term pregnancy, because the father (Nick Kroll) is 6 years old and has advanced aging disease; the doctors remember Lola who still seems to be dead; Chief has more than professional feelings for the new administrator; Glenn cures cancer.
Cat goes into labor and Lola turns out not to be dead.
Dr. Maestro asks Dr. Flame to give him a lethal injection so that he can find Dr. Spratt in the spirit world. A creepy EMT wants to show The Chief his "sexy" costume.
Blake tells Lola he knows her brain tumor is fake. Meanwhile, Glen tries to get revenge on Cat's new boyfriend.
The staff must choose between saving an old black man and a young white kid. Insult comic Jeffrey Ross brings his child into the O.R., but the staff is more concerned with enjoying his humor than treating his child. Two Star Trek nerds dressed in uniforms (one as a Klingon) visit the hospital.
An episode of TV news magazine News Readers covering the filming of the final episode of Childrens Hospital, complete with behind the scenes looks at the show. Cutter Spindell (who portrays Blake Downs on the show within the show) interferes to save the series, convincing protesters that they're saving an actual children's hospital.
Rob Corddry
Dr. Blake Downs
Malin Åkerman
Dr. Valerie Flame
Lake Bell
Dr. Cat Black
Erinn Hayes
Dr. Lola Spratt
Rob Huebel
Dr. Owen Maestro